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Juvenile Huntingtons occurs in approximately 16 of all cases. There does not appear to be a difference in the numbers for men and women while some variance is recorded.

Evaluating The Current State Of The Art Of Huntington Disease Research A Scientometric Analysis

It is concluded that most European populations both Northern and Southern show a relatively high prevalence 48 per 100000 and that the disorder may also be frequent in India and parts of central Asia.

Prevalence of huntington's disease. 1 The disease runs in families and it is always caused by an inherited gene. In South Africa lower rates are seen in black populations compared to white and mixed populations. 11 Accurate estimates of the incidence of HD are not available.

HD is a genetic neurodegenerative and ultimately fatal disease. 4567 Canadian studies suggested 24-84 persons per 100000 had HD. Experts estimate that one in every 10000 persons-nearly 30000 in the United States-have Huntingtons disease.

Worldwide prevalence of Huntingtons disease HD is quite heterogenous. Huntingtons disease has a prevalence of 106137 individuals per 100 000 in Western populations. 89 In the United States it was estimated that 41 52 persons per 100000 were living with thedisorder.

The epidemiology of HD thus depends on ascertainment of individuals with the expanded CAG mutation and on examination of clinical signs to accurately assess disease. The frequency of Huntingtons disease HD may vary considerably with higher estimates in non Asian populations. Huntingtons disease occurs in 27 per 100000 inhabitants worldwide and 10 per 100000 in Europe according to a new report Rare Disease Clinical Research.

Incidence and Prevalence of Huntingtons Disease. This variation can in part be attributed to differences in case-ascertainment andor diagnostic criteria but there is consistent evidence of a lower incidence in Asian populations. Huntingtons disease is a rare condition affecting approximately 122 out of every 100000 people in the United States.

Using multiple sources for ascertainment of HD cases although time-consuming is more likely to. The Prevalence of Huntingtons Disease The prevalence of HD varies more than tenfold between different geographical regions. To review the existing literature on the prevalence of Huntingtons disease HD in the US and Canada and to estimate the number of people in the US currently affected by this disease.

The estimated prevalence of HD in North America North Western Europe and Australia ranges from 596 to 137 cases per 100 000 population. The prevalence is 04 per 100000 people in Hong Kong and 065 per 100000 in Japan. The prevalence of HD in the West is estimated at five to ten people per 100000 people.

We reviewed the literature on HD prevalence. Untapped Potential in MENA But 21 of every 100000 Egyptians has the disease which translates into roughly 21000 patients. In Europe it was estimated that an average of 4-7 persons per 100000 were affected with the disease.

Huntingtons disease is not prevalent within any particular population. HD is notably rare in Finland and in Japan. The Huntingtons Disease Association has 6376 symptomatic people on its books in England which works out at 124 per 100 000 In other words if these figures accurately reflect the UK situation the prevalence of Huntingtons disease has been underestimated by 80.

In India there are case reports from Punjab and northern India and until 1990 there were 69 case reports of HD in. Huntington disease HD is an autosomal-dominant neurologic disorder caused by an expanded CAG trinucleotide repeat mutation in patients with characteristic motor signs and specific brain pathology. Estimates of the prevalence of HD in the United States range from 41-84 per 100000 people.

1011 Figure 1 reviews additional global prevalence estimates for HD. In Italy two recent studies performed in Ferrara county and Molise provided different prevalence estimates varying from 42 10 5 to 108 10 5. Prevalence of Huntingtons Disease Worldwide Around the world cases of Huntingtons disease are found in 5-10 out of 100000 people.

The ascertained prevalence of HD in Asia is much lower than Western populations. As Italy is characterized by significant genetic heterogeneity with presumptive differences between Italian regions this review was undertaken to define available data of HD prevalence in Italy to assess geographic heterogeneity and reconcile possible variation in HD prevalence rates with the availability of genetic. Sources frequently state that 30000 individuals living in the US have HD but the methodology used to derive this prevalence estimate is unclear.

Because the figures from the Huntingtons Disease Association are themselves almost certainly an underestimate Rawlins says it. However in Asia the prevalence of HD is approximately one tenth of the HD prevalence in Western population. There is also evidence that in A.

A repeat of 36 CAG or more can lead to the disease with increased penetrance and decreased age of onset at longer CAG repeats. Japan Taiwan and Hong Kong have a much lower incidence of HD with a prevalence of 17 per million.